Oral Contraceptives and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Oral Contraceptives and Rifampicin unless specifically directed by your doctor.
How Oral Contraceptives interacts with Rifampicin
Rifampicin induces CYP3A4 metabolism of estrogens and progestogens, reducing contraceptive plasma levels and efficacy.
What you should do
Use an alternative or additional non-hormonal contraceptive method during rifampicin therapy and for 4 weeks after discontinuation.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin induces CYP3A4 metabolism of estrogens and progestogens, reducing contraceptive plasma levels and efficacy.
Action
Use an alternative or additional non-hormonal contraceptive method during rifampicin therapy and for 4 weeks after disco...
Frequently asked questions
Can I take Oral Contraceptives and Rifampicin together?
No — this combination should generally be avoided. Use an alternative or additional non-hormonal contraceptive method during rifampicin therapy and for 4 weeks after discontinuation.
What is the severity of this interaction?
The interaction between Oral Contraceptives and Rifampicin is classified as Major — avoid combination. Rifampicin induces CYP3A4 metabolism of estrogens and progestogens, reducing contraceptive plasma levels and efficacy.
What should I do if I'm prescribed both?
Use an alternative or additional non-hormonal contraceptive method during rifampicin therapy and for 4 weeks after discontinuation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.