Rifampicin and Voriconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Rifampicin and Voriconazole unless specifically directed by your doctor.
How Rifampicin interacts with Voriconazole
Rifampicin induces CYP2C19 and CYP3A4, reducing voriconazole exposure by more than 90% and rendering antifungal therapy ineffective.
What you should do
Concomitant use is contraindicated. Choose an alternative antifungal or replace rifampicin with rifabutin with voriconazole dose adjustment.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin induces CYP2C19 and CYP3A4, reducing voriconazole exposure by more than 90% and rendering antifungal therapy ...
Action
Concomitant use is contraindicated. Choose an alternative antifungal or replace rifampicin with rifabutin with voriconaz...
Frequently asked questions
Can I take Rifampicin and Voriconazole together?
No — this combination should generally be avoided. Concomitant use is contraindicated. Choose an alternative antifungal or replace rifampicin with rifabutin with voriconazole dose adjustment.
What is the severity of this interaction?
The interaction between Rifampicin and Voriconazole is classified as Major — avoid combination. Rifampicin induces CYP2C19 and CYP3A4, reducing voriconazole exposure by more than 90% and rendering antifungal therapy ineffective.
What should I do if I'm prescribed both?
Concomitant use is contraindicated. Choose an alternative antifungal or replace rifampicin with rifabutin with voriconazole dose adjustment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.