Probenecid and Tenofovir Disoproxil: Drug Interaction Guide

Quick answer: This combination requires caution. Probenecid and Tenofovir Disoproxil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Probenecid interacts with Tenofovir Disoproxil

Probenecid inhibits renal organic anion transporters involved in tubular secretion of tenofovir. This may increase tenofovir exposure and nephrotoxicity risk.

What you should do

Avoid if possible in patients with renal risk factors. Monitor renal function, phosphate, and urine protein if coadministration is necessary.

Key facts

Severity

Moderate — caution required

Mechanism

Probenecid inhibits renal organic anion transporters involved in tubular secretion of tenofovir. This may increase tenof...

Action

Avoid if possible in patients with renal risk factors. Monitor renal function, phosphate, and urine protein if coadminis...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Probenecid and Tenofovir Disoproxil together?

With caution. Avoid if possible in patients with renal risk factors. Monitor renal function, phosphate, and urine protein if coadministration is necessary.

What is the severity of this interaction?

The interaction between Probenecid and Tenofovir Disoproxil is classified as Moderate — caution required. Probenecid inhibits renal organic anion transporters involved in tubular secretion of tenofovir. This may increase tenofovir exposure and nephrotoxicity risk.

What should I do if I'm prescribed both?

Avoid if possible in patients with renal risk factors. Monitor renal function, phosphate, and urine protein if coadministration is necessary. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.