Probenecid and Zidovudine: Drug Interaction Guide
Quick answer: This combination requires caution. Probenecid and Zidovudine can be used together with adjustments and monitoring.
How Probenecid interacts with Zidovudine
Probenecid inhibits renal tubular secretion and glucuronidation pathways involved in zidovudine elimination. This can increase zidovudine exposure and toxicity risk.
What you should do
Use cautiously and monitor for zidovudine adverse effects such as anemia, neutropenia, and gastrointestinal toxicity. Dose adjustment may be required.
Key facts
Severity
Moderate — caution required
Mechanism
Probenecid inhibits renal tubular secretion and glucuronidation pathways involved in zidovudine elimination. This can in...
Action
Use cautiously and monitor for zidovudine adverse effects such as anemia, neutropenia, and gastrointestinal toxicity. Do...
Frequently asked questions
Can I take Probenecid and Zidovudine together?
With caution. Use cautiously and monitor for zidovudine adverse effects such as anemia, neutropenia, and gastrointestinal toxicity. Dose adjustment may be required.
What is the severity of this interaction?
The interaction between Probenecid and Zidovudine is classified as Moderate — caution required. Probenecid inhibits renal tubular secretion and glucuronidation pathways involved in zidovudine elimination. This can increase zidovudine exposure and toxicity risk.
What should I do if I'm prescribed both?
Use cautiously and monitor for zidovudine adverse effects such as anemia, neutropenia, and gastrointestinal toxicity. Dose adjustment may be required. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.