Ranolazine and Simvastatin: Drug Interaction Guide
Quick answer: This combination requires caution. Ranolazine and Simvastatin can be used together with adjustments and monitoring.
How Ranolazine interacts with Simvastatin
Ranolazine inhibits CYP3A4 and P-glycoprotein, increasing simvastatin exposure and the risk of myopathy.
What you should do
Limit simvastatin to 20 mg daily when co-administered with ranolazine, or switch to pravastatin or rosuvastatin which are not CYP3A4 substrates.
Key facts
Severity
Moderate — caution required
Mechanism
Ranolazine inhibits CYP3A4 and P-glycoprotein, increasing simvastatin exposure and the risk of myopathy.
Action
Limit simvastatin to 20 mg daily when co-administered with ranolazine, or switch to pravastatin or rosuvastatin which ar...
Frequently asked questions
Can I take Ranolazine and Simvastatin together?
With caution. Limit simvastatin to 20 mg daily when co-administered with ranolazine, or switch to pravastatin or rosuvastatin which are not CYP3A4 substrates.
What is the severity of this interaction?
The interaction between Ranolazine and Simvastatin is classified as Moderate — caution required. Ranolazine inhibits CYP3A4 and P-glycoprotein, increasing simvastatin exposure and the risk of myopathy.
What should I do if I'm prescribed both?
Limit simvastatin to 20 mg daily when co-administered with ranolazine, or switch to pravastatin or rosuvastatin which are not CYP3A4 substrates. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.