Simvastatin and Ticagrelor: Drug Interaction Guide

Quick answer: This combination requires caution. Simvastatin and Ticagrelor can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Simvastatin interacts with Ticagrelor

Ticagrelor inhibits CYP3A4, increasing simvastatin exposure and risk of myopathy and rhabdomyolysis.

What you should do

Limit simvastatin dose to 40 mg daily when co-administered with ticagrelor; consider rosuvastatin or pravastatin as alternatives.

Key facts

Severity

Moderate — caution required

Mechanism

Ticagrelor inhibits CYP3A4, increasing simvastatin exposure and risk of myopathy and rhabdomyolysis.

Action

Limit simvastatin dose to 40 mg daily when co-administered with ticagrelor; consider rosuvastatin or pravastatin as alte...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Simvastatin and Ticagrelor together?

With caution. Limit simvastatin dose to 40 mg daily when co-administered with ticagrelor; consider rosuvastatin or pravastatin as alternatives.

What is the severity of this interaction?

The interaction between Simvastatin and Ticagrelor is classified as Moderate — caution required. Ticagrelor inhibits CYP3A4, increasing simvastatin exposure and risk of myopathy and rhabdomyolysis.

What should I do if I'm prescribed both?

Limit simvastatin dose to 40 mg daily when co-administered with ticagrelor; consider rosuvastatin or pravastatin as alternatives. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.