Riociguat and Sildenafil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Riociguat and Sildenafil unless specifically directed by your doctor.
How Riociguat interacts with Sildenafil
Riociguat stimulates soluble guanylate cyclase and sildenafil inhibits phosphodiesterase type 5, causing excessive cyclic guanosine monophosphate accumulation and potentially severe hypotension.
What you should do
Do not coadminister these drugs. Use an alternative pulmonary-hypertension regimen under specialist supervision.
Key facts
Severity
Major — avoid combination
Mechanism
Riociguat stimulates soluble guanylate cyclase and sildenafil inhibits phosphodiesterase type 5, causing excessive cycli...
Action
Do not coadminister these drugs. Use an alternative pulmonary-hypertension regimen under specialist supervision.
Frequently asked questions
Can I take Riociguat and Sildenafil together?
No — this combination should generally be avoided. Do not coadminister these drugs. Use an alternative pulmonary-hypertension regimen under specialist supervision.
What is the severity of this interaction?
The interaction between Riociguat and Sildenafil is classified as Major — avoid combination. Riociguat stimulates soluble guanylate cyclase and sildenafil inhibits phosphodiesterase type 5, causing excessive cyclic guanosine monophosphate accumulation and potentially severe hypotension.
What should I do if I'm prescribed both?
Do not coadminister these drugs. Use an alternative pulmonary-hypertension regimen under specialist supervision. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.