Nitroglycerin and Sildenafil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Nitroglycerin and Sildenafil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Nitroglycerin interacts with Sildenafil

Sildenafil potentiates nitric oxide-mediated cGMP accumulation, and concomitant nitrate-induced cGMP elevation produces profound, unpredictable hypotension.

What you should do

Combination is contraindicated. Wait at least 24 hours after sildenafil (48 hours after tadalafil) before administering any nitrate; document the exposure in clinical handovers.

Key facts

Severity

Major — avoid combination

Mechanism

Sildenafil potentiates nitric oxide-mediated cGMP accumulation, and concomitant nitrate-induced cGMP elevation produces ...

Action

Combination is contraindicated. Wait at least 24 hours after sildenafil (48 hours after tadalafil) before administering ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nitroglycerin and Sildenafil together?

No — this combination should generally be avoided. Combination is contraindicated. Wait at least 24 hours after sildenafil (48 hours after tadalafil) before administering any nitrate; document the exposure in clinical handovers.

What is the severity of this interaction?

The interaction between Nitroglycerin and Sildenafil is classified as Major — avoid combination. Sildenafil potentiates nitric oxide-mediated cGMP accumulation, and concomitant nitrate-induced cGMP elevation produces profound, unpredictable hypotension.

What should I do if I'm prescribed both?

Combination is contraindicated. Wait at least 24 hours after sildenafil (48 hours after tadalafil) before administering any nitrate; document the exposure in clinical handovers. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.