Rivaroxaban and Verapamil: Drug Interaction Guide

Quick answer: This combination requires caution. Rivaroxaban and Verapamil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Rivaroxaban interacts with Verapamil

Verapamil is a moderate inhibitor of both CYP3A4 and P-glycoprotein, increasing rivaroxaban exposure by 30-40% and prolonging anticoagulant effect.

What you should do

Use with caution; in patients with creatinine clearance 15-50 mL/min, avoid combination or reduce rivaroxaban dose, and monitor for bleeding.

Key facts

Severity

Moderate — caution required

Mechanism

Verapamil is a moderate inhibitor of both CYP3A4 and P-glycoprotein, increasing rivaroxaban exposure by 30-40% and prolo...

Action

Use with caution; in patients with creatinine clearance 15-50 mL/min, avoid combination or reduce rivaroxaban dose, and ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Rivaroxaban and Verapamil together?

With caution. Use with caution; in patients with creatinine clearance 15-50 mL/min, avoid combination or reduce rivaroxaban dose, and monitor for bleeding.

What is the severity of this interaction?

The interaction between Rivaroxaban and Verapamil is classified as Moderate — caution required. Verapamil is a moderate inhibitor of both CYP3A4 and P-glycoprotein, increasing rivaroxaban exposure by 30-40% and prolonging anticoagulant effect.

What should I do if I'm prescribed both?

Use with caution; in patients with creatinine clearance 15-50 mL/min, avoid combination or reduce rivaroxaban dose, and monitor for bleeding. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.