Sotalol and Verapamil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Sotalol and Verapamil unless specifically directed by your doctor.
How Sotalol interacts with Verapamil
Sotalol has beta-blocking and QT-prolonging effects, while verapamil slows AV nodal conduction and reduces myocardial contractility. Additive electrophysiologic effects can cause bradycardia, heart block, or hypotension.
What you should do
Avoid routine coadministration. If specialist use is necessary, monitor ECG, heart rate, and blood pressure closely.
Key facts
Severity
Major — avoid combination
Mechanism
Sotalol has beta-blocking and QT-prolonging effects, while verapamil slows AV nodal conduction and reduces myocardial co...
Action
Avoid routine coadministration. If specialist use is necessary, monitor ECG, heart rate, and blood pressure closely.
Frequently asked questions
Can I take Sotalol and Verapamil together?
No — this combination should generally be avoided. Avoid routine coadministration. If specialist use is necessary, monitor ECG, heart rate, and blood pressure closely.
What is the severity of this interaction?
The interaction between Sotalol and Verapamil is classified as Major — avoid combination. Sotalol has beta-blocking and QT-prolonging effects, while verapamil slows AV nodal conduction and reduces myocardial contractility. Additive electrophysiologic effects can cause bradycardia, heart block, or hypotension.
What should I do if I'm prescribed both?
Avoid routine coadministration. If specialist use is necessary, monitor ECG, heart rate, and blood pressure closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.