Sotalol and Trazodone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Sotalol and Trazodone unless specifically directed by your doctor.
How Sotalol interacts with Trazodone
Sotalol prolongs cardiac repolarization through potassium channel blockade, and trazodone can also prolong the QT interval. Additive QT prolongation increases risk of torsades de pointes.
What you should do
Avoid combination when possible, especially in patients with bradycardia, hypokalemia, structural heart disease, or baseline QT prolongation. If unavoidable, obtain ECGs and correct electrolytes.
Key facts
Severity
Major — avoid combination
Mechanism
Sotalol prolongs cardiac repolarization through potassium channel blockade, and trazodone can also prolong the QT interv...
Action
Avoid combination when possible, especially in patients with bradycardia, hypokalemia, structural heart disease, or base...
Frequently asked questions
Can I take Sotalol and Trazodone together?
No — this combination should generally be avoided. Avoid combination when possible, especially in patients with bradycardia, hypokalemia, structural heart disease, or baseline QT prolongation. If unavoidable, obtain ECGs and correct electrolytes.
What is the severity of this interaction?
The interaction between Sotalol and Trazodone is classified as Major — avoid combination. Sotalol prolongs cardiac repolarization through potassium channel blockade, and trazodone can also prolong the QT interval. Additive QT prolongation increases risk of torsades de pointes.
What should I do if I'm prescribed both?
Avoid combination when possible, especially in patients with bradycardia, hypokalemia, structural heart disease, or baseline QT prolongation. If unavoidable, obtain ECGs and correct electrolytes. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.