Statin and Verapamil: Drug Interaction Guide
Quick answer: This combination requires caution. Statin and Verapamil can be used together with adjustments and monitoring.
How Statin interacts with Verapamil
Verapamil inhibits CYP3A4 and P-glycoprotein, increasing exposure of simvastatin, atorvastatin and lovastatin and raising myopathy and rhabdomyolysis risk.
What you should do
Limit simvastatin to 20 mg daily and atorvastatin to 20 mg daily with verapamil, or use pravastatin, fluvastatin or rosuvastatin.
Key facts
Severity
Moderate — caution required
Mechanism
Verapamil inhibits CYP3A4 and P-glycoprotein, increasing exposure of simvastatin, atorvastatin and lovastatin and raisin...
Action
Limit simvastatin to 20 mg daily and atorvastatin to 20 mg daily with verapamil, or use pravastatin, fluvastatin or rosu...
Frequently asked questions
Can I take Statin and Verapamil together?
With caution. Limit simvastatin to 20 mg daily and atorvastatin to 20 mg daily with verapamil, or use pravastatin, fluvastatin or rosuvastatin.
What is the severity of this interaction?
The interaction between Statin and Verapamil is classified as Moderate — caution required. Verapamil inhibits CYP3A4 and P-glycoprotein, increasing exposure of simvastatin, atorvastatin and lovastatin and raising myopathy and rhabdomyolysis risk.
What should I do if I'm prescribed both?
Limit simvastatin to 20 mg daily and atorvastatin to 20 mg daily with verapamil, or use pravastatin, fluvastatin or rosuvastatin. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.