Tadalafil and Tamsulosin: Drug Interaction Guide
Quick answer: This combination requires caution. Tadalafil and Tamsulosin can be used together with adjustments and monitoring.
How Tadalafil interacts with Tamsulosin
Both drugs cause vascular smooth-muscle relaxation via alpha-1 blockade and PDE5 inhibition respectively, with additive vasodilation and risk of orthostatic hypotension.
What you should do
Stabilise the patient on tamsulosin first, then add tadalafil at the lowest dose; warn about postural symptoms and avoid combining with other antihypertensives without monitoring.
Key facts
Severity
Moderate — caution required
Mechanism
Both drugs cause vascular smooth-muscle relaxation via alpha-1 blockade and PDE5 inhibition respectively, with additive ...
Action
Stabilise the patient on tamsulosin first, then add tadalafil at the lowest dose; warn about postural symptoms and avoid...
Frequently asked questions
Can I take Tadalafil and Tamsulosin together?
With caution. Stabilise the patient on tamsulosin first, then add tadalafil at the lowest dose; warn about postural symptoms and avoid combining with other antihypertensives without monitoring.
What is the severity of this interaction?
The interaction between Tadalafil and Tamsulosin is classified as Moderate — caution required. Both drugs cause vascular smooth-muscle relaxation via alpha-1 blockade and PDE5 inhibition respectively, with additive vasodilation and risk of orthostatic hypotension.
What should I do if I'm prescribed both?
Stabilise the patient on tamsulosin first, then add tadalafil at the lowest dose; warn about postural symptoms and avoid combining with other antihypertensives without monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.