Tadalafil and Terazosin: Drug Interaction Guide

Quick answer: This combination requires caution. Tadalafil and Terazosin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Tadalafil interacts with Terazosin

Tadalafil enhances nitric oxide-cGMP vasodilation, while terazosin causes alpha-1 receptor-mediated vasodilation. The combination can produce additive blood pressure lowering.

What you should do

Ensure the patient is stable on alpha-blocker therapy before adding tadalafil. Start with a low tadalafil dose and monitor for postural hypotension and syncope.

Key facts

Severity

Moderate — caution required

Mechanism

Tadalafil enhances nitric oxide-cGMP vasodilation, while terazosin causes alpha-1 receptor-mediated vasodilation. The co...

Action

Ensure the patient is stable on alpha-blocker therapy before adding tadalafil. Start with a low tadalafil dose and monit...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Tadalafil and Terazosin together?

With caution. Ensure the patient is stable on alpha-blocker therapy before adding tadalafil. Start with a low tadalafil dose and monitor for postural hypotension and syncope.

What is the severity of this interaction?

The interaction between Tadalafil and Terazosin is classified as Moderate — caution required. Tadalafil enhances nitric oxide-cGMP vasodilation, while terazosin causes alpha-1 receptor-mediated vasodilation. The combination can produce additive blood pressure lowering.

What should I do if I'm prescribed both?

Ensure the patient is stable on alpha-blocker therapy before adding tadalafil. Start with a low tadalafil dose and monitor for postural hypotension and syncope. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.