Ace Inhibitor and Lithium: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ace Inhibitor and Lithium unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ace Inhibitor interacts with Lithium

ACE inhibitors reduce renal clearance of lithium through decreased glomerular filtration and increased proximal tubular reabsorption, leading to elevated lithium levels and potential toxicity.

What you should do

Avoid combination where possible. If unavoidable, monitor lithium levels within 5-7 days of initiation and after any dose change.

Key facts

Severity

Major — avoid combination

Mechanism

ACE inhibitors reduce renal clearance of lithium through decreased glomerular filtration and increased proximal tubular ...

Action

Avoid combination where possible. If unavoidable, monitor lithium levels within 5-7 days of initiation and after any dos...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ace Inhibitor and Lithium together?

No — this combination should generally be avoided. Avoid combination where possible. If unavoidable, monitor lithium levels within 5-7 days of initiation and after any dose change.

What is the severity of this interaction?

The interaction between Ace Inhibitor and Lithium is classified as Major — avoid combination. ACE inhibitors reduce renal clearance of lithium through decreased glomerular filtration and increased proximal tubular reabsorption, leading to elevated lithium levels and potential toxicity.

What should I do if I'm prescribed both?

Avoid combination where possible. If unavoidable, monitor lithium levels within 5-7 days of initiation and after any dose change. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.