Ace Inhibitor and Sacubitril Valsartan: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ace Inhibitor and Sacubitril Valsartan unless specifically directed by your doctor.
How Ace Inhibitor interacts with Sacubitril Valsartan
Concurrent neprilysin inhibition and ACE inhibition raise bradykinin levels markedly, substantially increasing the risk of angioedema.
What you should do
Discontinue ACE inhibitor at least 36 hours before initiating sacubitril-valsartan; never co-administer.
Key facts
Severity
Major — avoid combination
Mechanism
Concurrent neprilysin inhibition and ACE inhibition raise bradykinin levels markedly, substantially increasing the risk ...
Action
Discontinue ACE inhibitor at least 36 hours before initiating sacubitril-valsartan; never co-administer.
Frequently asked questions
Can I take Ace Inhibitor and Sacubitril Valsartan together?
No — this combination should generally be avoided. Discontinue ACE inhibitor at least 36 hours before initiating sacubitril-valsartan; never co-administer.
What is the severity of this interaction?
The interaction between Ace Inhibitor and Sacubitril Valsartan is classified as Major — avoid combination. Concurrent neprilysin inhibition and ACE inhibition raise bradykinin levels markedly, substantially increasing the risk of angioedema.
What should I do if I'm prescribed both?
Discontinue ACE inhibitor at least 36 hours before initiating sacubitril-valsartan; never co-administer. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.