Alprazolam and Itraconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Alprazolam and Itraconazole unless specifically directed by your doctor.
How Alprazolam interacts with Itraconazole
Itraconazole is a potent CYP3A4 inhibitor that doubles alprazolam AUC and prolongs its half-life, producing excessive sedation and respiratory depression.
What you should do
Avoid alprazolam during itraconazole therapy; substitute lorazepam or oxazepam which undergo conjugation rather than CYP3A4 metabolism.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole is a potent CYP3A4 inhibitor that doubles alprazolam AUC and prolongs its half-life, producing excessive se...
Action
Avoid alprazolam during itraconazole therapy; substitute lorazepam or oxazepam which undergo conjugation rather than CYP...
Frequently asked questions
Can I take Alprazolam and Itraconazole together?
No — this combination should generally be avoided. Avoid alprazolam during itraconazole therapy; substitute lorazepam or oxazepam which undergo conjugation rather than CYP3A4 metabolism.
What is the severity of this interaction?
The interaction between Alprazolam and Itraconazole is classified as Major — avoid combination. Itraconazole is a potent CYP3A4 inhibitor that doubles alprazolam AUC and prolongs its half-life, producing excessive sedation and respiratory depression.
What should I do if I'm prescribed both?
Avoid alprazolam during itraconazole therapy; substitute lorazepam or oxazepam which undergo conjugation rather than CYP3A4 metabolism. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.