Amphotericin B and Digoxin: Drug Interaction Guide

Quick answer: This combination requires caution. Amphotericin B and Digoxin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Amphotericin B interacts with Digoxin

Amphotericin B can cause renal potassium and magnesium loss, increasing myocardial sensitivity to digoxin and the risk of arrhythmias.

What you should do

Monitor potassium, magnesium, renal function, ECG findings, and digoxin concentrations. Correct electrolyte abnormalities promptly.

Key facts

Severity

Moderate — caution required

Mechanism

Amphotericin B can cause renal potassium and magnesium loss, increasing myocardial sensitivity to digoxin and the risk o...

Action

Monitor potassium, magnesium, renal function, ECG findings, and digoxin concentrations. Correct electrolyte abnormalitie...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amphotericin B and Digoxin together?

With caution. Monitor potassium, magnesium, renal function, ECG findings, and digoxin concentrations. Correct electrolyte abnormalities promptly.

What is the severity of this interaction?

The interaction between Amphotericin B and Digoxin is classified as Moderate — caution required. Amphotericin B can cause renal potassium and magnesium loss, increasing myocardial sensitivity to digoxin and the risk of arrhythmias.

What should I do if I'm prescribed both?

Monitor potassium, magnesium, renal function, ECG findings, and digoxin concentrations. Correct electrolyte abnormalities promptly. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.