Digoxin and Erythromycin: Drug Interaction Guide

Quick answer: This combination requires caution. Digoxin and Erythromycin can be used together with adjustments and monitoring.

How Digoxin interacts with Erythromycin

Erythromycin inhibits intestinal P-glycoprotein and gut flora that inactivate digoxin in some patients, increasing digoxin bioavailability and serum levels.

What you should do

Monitor digoxin levels during erythromycin therapy and watch for signs of toxicity; consider 30-50% dose reduction.

Key facts

Severity

Moderate — caution required

Mechanism

Erythromycin inhibits intestinal P-glycoprotein and gut flora that inactivate digoxin in some patients, increasing digox...

Action

Monitor digoxin levels during erythromycin therapy and watch for signs of toxicity; consider 30-50% dose reduction.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Digoxin and Erythromycin together?

With caution. Monitor digoxin levels during erythromycin therapy and watch for signs of toxicity; consider 30-50% dose reduction.

What is the severity of this interaction?

The interaction between Digoxin and Erythromycin is classified as Moderate — caution required. Erythromycin inhibits intestinal P-glycoprotein and gut flora that inactivate digoxin in some patients, increasing digoxin bioavailability and serum levels.

What should I do if I'm prescribed both?

Monitor digoxin levels during erythromycin therapy and watch for signs of toxicity; consider 30-50% dose reduction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 18, 2026 by iMedic Medical Editorial Team. Our editorial process.