Apixaban and Carbamazepine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Apixaban and Carbamazepine unless specifically directed by your doctor.
How Apixaban interacts with Carbamazepine
Carbamazepine induces CYP3A4 and P-glycoprotein, reducing apixaban plasma concentrations and predisposing to thromboembolic failure.
What you should do
Avoid co-administration; if anticoagulation is required, switch to a vitamin-K antagonist with INR monitoring or LMWH.
Key facts
Severity
Major — avoid combination
Mechanism
Carbamazepine induces CYP3A4 and P-glycoprotein, reducing apixaban plasma concentrations and predisposing to thromboembo...
Action
Avoid co-administration; if anticoagulation is required, switch to a vitamin-K antagonist with INR monitoring or LMWH.
Frequently asked questions
Can I take Apixaban and Carbamazepine together?
No — this combination should generally be avoided. Avoid co-administration; if anticoagulation is required, switch to a vitamin-K antagonist with INR monitoring or LMWH.
What is the severity of this interaction?
The interaction between Apixaban and Carbamazepine is classified as Major — avoid combination. Carbamazepine induces CYP3A4 and P-glycoprotein, reducing apixaban plasma concentrations and predisposing to thromboembolic failure.
What should I do if I'm prescribed both?
Avoid co-administration; if anticoagulation is required, switch to a vitamin-K antagonist with INR monitoring or LMWH. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.