Carbamazepine and Voriconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Carbamazepine and Voriconazole unless specifically directed by your doctor.
How Carbamazepine interacts with Voriconazole
Carbamazepine strongly induces CYP3A4 and CYP2C19, reducing voriconazole concentrations to subtherapeutic levels.
What you should do
Concomitant use is contraindicated. Substitute an alternative anticonvulsant (e.g. levetiracetam) or antifungal (e.g. liposomal amphotericin B).
Key facts
Severity
Major — avoid combination
Mechanism
Carbamazepine strongly induces CYP3A4 and CYP2C19, reducing voriconazole concentrations to subtherapeutic levels.
Action
Concomitant use is contraindicated. Substitute an alternative anticonvulsant (e.g. levetiracetam) or antifungal (e.g. li...
Frequently asked questions
Can I take Carbamazepine and Voriconazole together?
No — this combination should generally be avoided. Concomitant use is contraindicated. Substitute an alternative anticonvulsant (e.g. levetiracetam) or antifungal (e.g. liposomal amphotericin B).
What is the severity of this interaction?
The interaction between Carbamazepine and Voriconazole is classified as Major — avoid combination. Carbamazepine strongly induces CYP3A4 and CYP2C19, reducing voriconazole concentrations to subtherapeutic levels.
What should I do if I'm prescribed both?
Concomitant use is contraindicated. Substitute an alternative anticonvulsant (e.g. levetiracetam) or antifungal (e.g. liposomal amphotericin B). Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.