Apixaban and Diltiazem: Drug Interaction Guide
Quick answer: This combination requires caution. Apixaban and Diltiazem can be used together with adjustments and monitoring.
How Apixaban interacts with Diltiazem
Diltiazem moderately inhibits CYP3A4 and P-glycoprotein, raising apixaban plasma concentrations and increasing bleeding risk.
What you should do
Use standard dose of apixaban with close monitoring for bleeding; consider dose reduction in patients with additional risk factors (age >80, weight <60 kg, renal impairment).
Key facts
Severity
Moderate — caution required
Mechanism
Diltiazem moderately inhibits CYP3A4 and P-glycoprotein, raising apixaban plasma concentrations and increasing bleeding ...
Action
Use standard dose of apixaban with close monitoring for bleeding; consider dose reduction in patients with additional ri...
Frequently asked questions
Can I take Apixaban and Diltiazem together?
With caution. Use standard dose of apixaban with close monitoring for bleeding; consider dose reduction in patients with additional risk factors (age >80, weight <60 kg, renal impairment).
What is the severity of this interaction?
The interaction between Apixaban and Diltiazem is classified as Moderate — caution required. Diltiazem moderately inhibits CYP3A4 and P-glycoprotein, raising apixaban plasma concentrations and increasing bleeding risk.
What should I do if I'm prescribed both?
Use standard dose of apixaban with close monitoring for bleeding; consider dose reduction in patients with additional risk factors (age >80, weight <60 kg, renal impairment). Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.