Diltiazem and Rivaroxaban: Drug Interaction Guide

Quick answer: This combination requires caution. Diltiazem and Rivaroxaban can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Diltiazem interacts with Rivaroxaban

Diltiazem inhibits CYP3A4 and P-glycoprotein, potentially increasing rivaroxaban exposure. Bleeding risk may be higher, particularly with renal impairment.

What you should do

Use cautiously and monitor for bleeding. Consider alternative rate-control therapy or anticoagulation strategy in high-risk patients.

Key facts

Severity

Moderate — caution required

Mechanism

Diltiazem inhibits CYP3A4 and P-glycoprotein, potentially increasing rivaroxaban exposure. Bleeding risk may be higher, ...

Action

Use cautiously and monitor for bleeding. Consider alternative rate-control therapy or anticoagulation strategy in high-r...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diltiazem and Rivaroxaban together?

With caution. Use cautiously and monitor for bleeding. Consider alternative rate-control therapy or anticoagulation strategy in high-risk patients.

What is the severity of this interaction?

The interaction between Diltiazem and Rivaroxaban is classified as Moderate — caution required. Diltiazem inhibits CYP3A4 and P-glycoprotein, potentially increasing rivaroxaban exposure. Bleeding risk may be higher, particularly with renal impairment.

What should I do if I'm prescribed both?

Use cautiously and monitor for bleeding. Consider alternative rate-control therapy or anticoagulation strategy in high-risk patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.