Diltiazem and Everolimus: Drug Interaction Guide

Quick answer: This combination requires caution. Diltiazem and Everolimus can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Diltiazem interacts with Everolimus

Diltiazem inhibits CYP3A4 and P-glycoprotein, increasing everolimus AUC roughly twofold and risking immunosuppressant toxicity.

What you should do

Monitor everolimus trough concentrations; reduce dose as needed and watch for stomatitis, hyperlipidaemia, and cytopenias.

Key facts

Severity

Moderate — caution required

Mechanism

Diltiazem inhibits CYP3A4 and P-glycoprotein, increasing everolimus AUC roughly twofold and risking immunosuppressant to...

Action

Monitor everolimus trough concentrations; reduce dose as needed and watch for stomatitis, hyperlipidaemia, and cytopenia...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diltiazem and Everolimus together?

With caution. Monitor everolimus trough concentrations; reduce dose as needed and watch for stomatitis, hyperlipidaemia, and cytopenias.

What is the severity of this interaction?

The interaction between Diltiazem and Everolimus is classified as Moderate — caution required. Diltiazem inhibits CYP3A4 and P-glycoprotein, increasing everolimus AUC roughly twofold and risking immunosuppressant toxicity.

What should I do if I'm prescribed both?

Monitor everolimus trough concentrations; reduce dose as needed and watch for stomatitis, hyperlipidaemia, and cytopenias. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.