Apixaban and Enzalutamide: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Apixaban and Enzalutamide unless specifically directed by your doctor.
How Apixaban interacts with Enzalutamide
Enzalutamide strongly induces CYP3A4 and can substantially reduce exposure to apixaban, which is partly metabolized by CYP3A4. Reduced apixaban exposure may result in loss of anticoagulant efficacy.
What you should do
Avoid the combination and select an anticoagulant that is not substantially affected by strong CYP3A4 induction.
Key facts
Severity
Major — avoid combination
Mechanism
Enzalutamide strongly induces CYP3A4 and can substantially reduce exposure to apixaban, which is partly metabolized by C...
Action
Avoid the combination and select an anticoagulant that is not substantially affected by strong CYP3A4 induction.
Frequently asked questions
Can I take Apixaban and Enzalutamide together?
No — this combination should generally be avoided. Avoid the combination and select an anticoagulant that is not substantially affected by strong CYP3A4 induction.
What is the severity of this interaction?
The interaction between Apixaban and Enzalutamide is classified as Major — avoid combination. Enzalutamide strongly induces CYP3A4 and can substantially reduce exposure to apixaban, which is partly metabolized by CYP3A4. Reduced apixaban exposure may result in loss of anticoagulant efficacy.
What should I do if I'm prescribed both?
Avoid the combination and select an anticoagulant that is not substantially affected by strong CYP3A4 induction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.