Apixaban and Itraconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Apixaban and Itraconazole unless specifically directed by your doctor.
How Apixaban interacts with Itraconazole
Itraconazole is a strong inhibitor of both CYP3A4 and P-glycoprotein, leading to substantially increased apixaban plasma concentrations and bleeding risk.
What you should do
Avoid concomitant use. If unavoidable, consider switching to an alternative anticoagulant or antifungal; dose reduction of apixaban is not recommended in this combination.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole is a strong inhibitor of both CYP3A4 and P-glycoprotein, leading to substantially increased apixaban plasma...
Action
Avoid concomitant use. If unavoidable, consider switching to an alternative anticoagulant or antifungal; dose reduction ...
Frequently asked questions
Can I take Apixaban and Itraconazole together?
No — this combination should generally be avoided. Avoid concomitant use. If unavoidable, consider switching to an alternative anticoagulant or antifungal; dose reduction of apixaban is not recommended in this combination.
What is the severity of this interaction?
The interaction between Apixaban and Itraconazole is classified as Major — avoid combination. Itraconazole is a strong inhibitor of both CYP3A4 and P-glycoprotein, leading to substantially increased apixaban plasma concentrations and bleeding risk.
What should I do if I'm prescribed both?
Avoid concomitant use. If unavoidable, consider switching to an alternative anticoagulant or antifungal; dose reduction of apixaban is not recommended in this combination. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.