Apixaban and Fluconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Apixaban and Fluconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Apixaban interacts with Fluconazole

Fluconazole inhibits CYP3A4 and may inhibit P-glycoprotein, increasing apixaban exposure. This can increase bleeding risk.

What you should do

Assess bleeding risk and renal function before co-prescribing. Consider an alternative antifungal or enhanced clinical monitoring for bruising, bleeding, and anemia.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP3A4 and may inhibit P-glycoprotein, increasing apixaban exposure. This can increase bleeding ris...

Action

Assess bleeding risk and renal function before co-prescribing. Consider an alternative antifungal or enhanced clinical m...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Apixaban and Fluconazole together?

With caution. Assess bleeding risk and renal function before co-prescribing. Consider an alternative antifungal or enhanced clinical monitoring for bruising, bleeding, and anemia.

What is the severity of this interaction?

The interaction between Apixaban and Fluconazole is classified as Moderate — caution required. Fluconazole inhibits CYP3A4 and may inhibit P-glycoprotein, increasing apixaban exposure. This can increase bleeding risk.

What should I do if I'm prescribed both?

Assess bleeding risk and renal function before co-prescribing. Consider an alternative antifungal or enhanced clinical monitoring for bruising, bleeding, and anemia. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.