Atomoxetine and Fluoxetine: Drug Interaction Guide

Quick answer: This combination requires caution. Atomoxetine and Fluoxetine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Atomoxetine interacts with Fluoxetine

Fluoxetine inhibits CYP2D6, the main enzyme metabolizing atomoxetine, increasing atomoxetine exposure 6-8 fold in extensive metabolizers.

What you should do

Start atomoxetine at 0.5 mg/kg/day and titrate slowly only if clinically necessary; monitor for cardiovascular and GI adverse effects.

Key facts

Severity

Moderate — caution required

Mechanism

Fluoxetine inhibits CYP2D6, the main enzyme metabolizing atomoxetine, increasing atomoxetine exposure 6-8 fold in extens...

Action

Start atomoxetine at 0.5 mg/kg/day and titrate slowly only if clinically necessary; monitor for cardiovascular and GI ad...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Atomoxetine and Fluoxetine together?

With caution. Start atomoxetine at 0.5 mg/kg/day and titrate slowly only if clinically necessary; monitor for cardiovascular and GI adverse effects.

What is the severity of this interaction?

The interaction between Atomoxetine and Fluoxetine is classified as Moderate — caution required. Fluoxetine inhibits CYP2D6, the main enzyme metabolizing atomoxetine, increasing atomoxetine exposure 6-8 fold in extensive metabolizers.

What should I do if I'm prescribed both?

Start atomoxetine at 0.5 mg/kg/day and titrate slowly only if clinically necessary; monitor for cardiovascular and GI adverse effects. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.