Fluoxetine and Metoprolol: Drug Interaction Guide

Quick answer: This combination requires caution. Fluoxetine and Metoprolol can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Fluoxetine interacts with Metoprolol

Fluoxetine and its metabolite norfluoxetine are potent CYP2D6 inhibitors; metoprolol is a CYP2D6 substrate, so concurrent use can substantially increase metoprolol exposure, producing bradycardia and hypotension.

What you should do

Start metoprolol at a low dose, titrate carefully, and monitor heart rate and blood pressure; consider an alternative beta-blocker such as bisoprolol or atenolol.

Key facts

Severity

Moderate — caution required

Mechanism

Fluoxetine and its metabolite norfluoxetine are potent CYP2D6 inhibitors; metoprolol is a CYP2D6 substrate, so concurren...

Action

Start metoprolol at a low dose, titrate carefully, and monitor heart rate and blood pressure; consider an alternative be...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Fluoxetine and Metoprolol together?

With caution. Start metoprolol at a low dose, titrate carefully, and monitor heart rate and blood pressure; consider an alternative beta-blocker such as bisoprolol or atenolol.

What is the severity of this interaction?

The interaction between Fluoxetine and Metoprolol is classified as Moderate — caution required. Fluoxetine and its metabolite norfluoxetine are potent CYP2D6 inhibitors; metoprolol is a CYP2D6 substrate, so concurrent use can substantially increase metoprolol exposure, producing bradycardia and hypotension.

What should I do if I'm prescribed both?

Start metoprolol at a low dose, titrate carefully, and monitor heart rate and blood pressure; consider an alternative beta-blocker such as bisoprolol or atenolol. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.