Atomoxetine and Paroxetine: Drug Interaction Guide
Quick answer: This combination requires caution. Atomoxetine and Paroxetine can be used together with adjustments and monitoring.
How Atomoxetine interacts with Paroxetine
Paroxetine is a potent CYP2D6 inhibitor that increases atomoxetine plasma levels several-fold, raising the risk of tachycardia, hypertension, and insomnia.
What you should do
Initiate atomoxetine at the standard starting dose but only titrate upward if tolerated after 4 weeks, or choose an alternative SSRI such as sertraline.
Key facts
Severity
Moderate — caution required
Mechanism
Paroxetine is a potent CYP2D6 inhibitor that increases atomoxetine plasma levels several-fold, raising the risk of tachy...
Action
Initiate atomoxetine at the standard starting dose but only titrate upward if tolerated after 4 weeks, or choose an alte...
Frequently asked questions
Can I take Atomoxetine and Paroxetine together?
With caution. Initiate atomoxetine at the standard starting dose but only titrate upward if tolerated after 4 weeks, or choose an alternative SSRI such as sertraline.
What is the severity of this interaction?
The interaction between Atomoxetine and Paroxetine is classified as Moderate — caution required. Paroxetine is a potent CYP2D6 inhibitor that increases atomoxetine plasma levels several-fold, raising the risk of tachycardia, hypertension, and insomnia.
What should I do if I'm prescribed both?
Initiate atomoxetine at the standard starting dose but only titrate upward if tolerated after 4 weeks, or choose an alternative SSRI such as sertraline. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.