Atorvastatin and Cyclosporine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Atorvastatin and Cyclosporine unless specifically directed by your doctor.
How Atorvastatin interacts with Cyclosporine
Cyclosporine inhibits OATP1B1 uptake and CYP3A4 metabolism of atorvastatin, increasing statin exposure several-fold and substantially raising risk of myopathy and rhabdomyolysis.
What you should do
Limit atorvastatin to a maximum of 10 mg daily when co-administered with cyclosporine, or switch to pravastatin/fluvastatin with monitoring of creatine kinase.
Key facts
Severity
Major — avoid combination
Mechanism
Cyclosporine inhibits OATP1B1 uptake and CYP3A4 metabolism of atorvastatin, increasing statin exposure several-fold and ...
Action
Limit atorvastatin to a maximum of 10 mg daily when co-administered with cyclosporine, or switch to pravastatin/fluvasta...
Frequently asked questions
Can I take Atorvastatin and Cyclosporine together?
No — this combination should generally be avoided. Limit atorvastatin to a maximum of 10 mg daily when co-administered with cyclosporine, or switch to pravastatin/fluvastatin with monitoring of creatine kinase.
What is the severity of this interaction?
The interaction between Atorvastatin and Cyclosporine is classified as Major — avoid combination. Cyclosporine inhibits OATP1B1 uptake and CYP3A4 metabolism of atorvastatin, increasing statin exposure several-fold and substantially raising risk of myopathy and rhabdomyolysis.
What should I do if I'm prescribed both?
Limit atorvastatin to a maximum of 10 mg daily when co-administered with cyclosporine, or switch to pravastatin/fluvastatin with monitoring of creatine kinase. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.