Cyclosporine and Voriconazole: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Cyclosporine and Voriconazole unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Cyclosporine interacts with Voriconazole

Voriconazole inhibits CYP3A4, reducing cyclosporine metabolism and increasing cyclosporine concentrations. This increases nephrotoxicity, hypertension, and neurotoxicity risk.

What you should do

Reduce cyclosporine dose according to guidance and monitor trough concentrations and renal function closely.

Key facts

Severity

Major — avoid combination

Mechanism

Voriconazole inhibits CYP3A4, reducing cyclosporine metabolism and increasing cyclosporine concentrations. This increase...

Action

Reduce cyclosporine dose according to guidance and monitor trough concentrations and renal function closely.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cyclosporine and Voriconazole together?

No — this combination should generally be avoided. Reduce cyclosporine dose according to guidance and monitor trough concentrations and renal function closely.

What is the severity of this interaction?

The interaction between Cyclosporine and Voriconazole is classified as Major — avoid combination. Voriconazole inhibits CYP3A4, reducing cyclosporine metabolism and increasing cyclosporine concentrations. This increases nephrotoxicity, hypertension, and neurotoxicity risk.

What should I do if I'm prescribed both?

Reduce cyclosporine dose according to guidance and monitor trough concentrations and renal function closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.