Cyclosporine and Statins: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Cyclosporine and Statins unless specifically directed by your doctor.
How Cyclosporine interacts with Statins
Cyclosporine inhibits OATP1B1 hepatic uptake and CYP3A4 metabolism of most statins, raising statin exposure several-fold and markedly increasing risk of rhabdomyolysis.
What you should do
Limit statin doses (e.g. atorvastatin maximum 10 mg, rosuvastatin maximum 5 mg) or use pravastatin/fluvastatin with caution and monitor CK.
Key facts
Severity
Major — avoid combination
Mechanism
Cyclosporine inhibits OATP1B1 hepatic uptake and CYP3A4 metabolism of most statins, raising statin exposure several-fold...
Action
Limit statin doses (e.g. atorvastatin maximum 10 mg, rosuvastatin maximum 5 mg) or use pravastatin/fluvastatin with caut...
Frequently asked questions
Can I take Cyclosporine and Statins together?
No — this combination should generally be avoided. Limit statin doses (e.g. atorvastatin maximum 10 mg, rosuvastatin maximum 5 mg) or use pravastatin/fluvastatin with caution and monitor CK.
What is the severity of this interaction?
The interaction between Cyclosporine and Statins is classified as Major — avoid combination. Cyclosporine inhibits OATP1B1 hepatic uptake and CYP3A4 metabolism of most statins, raising statin exposure several-fold and markedly increasing risk of rhabdomyolysis.
What should I do if I'm prescribed both?
Limit statin doses (e.g. atorvastatin maximum 10 mg, rosuvastatin maximum 5 mg) or use pravastatin/fluvastatin with caution and monitor CK. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.