Atorvastatin and Itraconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Atorvastatin and Itraconazole unless specifically directed by your doctor.
How Atorvastatin interacts with Itraconazole
Itraconazole is a strong CYP3A4 inhibitor and reduces metabolism of atorvastatin. Increased atorvastatin exposure raises the risk of myopathy and rhabdomyolysis.
What you should do
Avoid or temporarily withhold atorvastatin during itraconazole treatment. If lipid therapy must continue, use a statin with less CYP3A4 dependence and monitor for muscle symptoms.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole is a strong CYP3A4 inhibitor and reduces metabolism of atorvastatin. Increased atorvastatin exposure raises...
Action
Avoid or temporarily withhold atorvastatin during itraconazole treatment. If lipid therapy must continue, use a statin w...
Frequently asked questions
Can I take Atorvastatin and Itraconazole together?
No — this combination should generally be avoided. Avoid or temporarily withhold atorvastatin during itraconazole treatment. If lipid therapy must continue, use a statin with less CYP3A4 dependence and monitor for muscle symptoms.
What is the severity of this interaction?
The interaction between Atorvastatin and Itraconazole is classified as Major — avoid combination. Itraconazole is a strong CYP3A4 inhibitor and reduces metabolism of atorvastatin. Increased atorvastatin exposure raises the risk of myopathy and rhabdomyolysis.
What should I do if I'm prescribed both?
Avoid or temporarily withhold atorvastatin during itraconazole treatment. If lipid therapy must continue, use a statin with less CYP3A4 dependence and monitor for muscle symptoms. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.