Azithromycin and Digoxin: Drug Interaction Guide

Quick answer: This combination requires caution. Azithromycin and Digoxin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Azithromycin interacts with Digoxin

Azithromycin disrupts intestinal flora that metabolize digoxin (Eggerthella lenta) and may inhibit P-glycoprotein, raising digoxin serum levels.

What you should do

Measure serum digoxin concentration during and after azithromycin courses, and watch for nausea, visual disturbance, or arrhythmia suggesting toxicity.

Key facts

Severity

Moderate — caution required

Mechanism

Azithromycin disrupts intestinal flora that metabolize digoxin (Eggerthella lenta) and may inhibit P-glycoprotein, raisi...

Action

Measure serum digoxin concentration during and after azithromycin courses, and watch for nausea, visual disturbance, or ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Azithromycin and Digoxin together?

With caution. Measure serum digoxin concentration during and after azithromycin courses, and watch for nausea, visual disturbance, or arrhythmia suggesting toxicity.

What is the severity of this interaction?

The interaction between Azithromycin and Digoxin is classified as Moderate — caution required. Azithromycin disrupts intestinal flora that metabolize digoxin (Eggerthella lenta) and may inhibit P-glycoprotein, raising digoxin serum levels.

What should I do if I'm prescribed both?

Measure serum digoxin concentration during and after azithromycin courses, and watch for nausea, visual disturbance, or arrhythmia suggesting toxicity. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.