Azithromycin and Hydroxychloroquine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Azithromycin and Hydroxychloroquine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Azithromycin interacts with Hydroxychloroquine

Both drugs block hERG potassium channels and prolong the QT interval; combined use produces additive risk of torsades de pointes and sudden cardiac death.

What you should do

Avoid combination, especially in patients with electrolyte disturbance or pre-existing QT prolongation; baseline and follow-up ECG if essential.

Key facts

Severity

Major — avoid combination

Mechanism

Both drugs block hERG potassium channels and prolong the QT interval; combined use produces additive risk of torsades de...

Action

Avoid combination, especially in patients with electrolyte disturbance or pre-existing QT prolongation; baseline and fol...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Azithromycin and Hydroxychloroquine together?

No — this combination should generally be avoided. Avoid combination, especially in patients with electrolyte disturbance or pre-existing QT prolongation; baseline and follow-up ECG if essential.

What is the severity of this interaction?

The interaction between Azithromycin and Hydroxychloroquine is classified as Major — avoid combination. Both drugs block hERG potassium channels and prolong the QT interval; combined use produces additive risk of torsades de pointes and sudden cardiac death.

What should I do if I'm prescribed both?

Avoid combination, especially in patients with electrolyte disturbance or pre-existing QT prolongation; baseline and follow-up ECG if essential. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.