Azithromycin and Domperidone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Azithromycin and Domperidone unless specifically directed by your doctor.
How Azithromycin interacts with Domperidone
Both drugs can prolong cardiac repolarization through effects on cardiac potassium channels, increasing risk of QT prolongation and torsades de pointes.
What you should do
Avoid co-prescribing where possible, especially in patients with cardiac disease, hypokalaemia, or other QT risk factors. Use alternative antiemetic or antibiotic therapy.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs can prolong cardiac repolarization through effects on cardiac potassium channels, increasing risk of QT prolo...
Action
Avoid co-prescribing where possible, especially in patients with cardiac disease, hypokalaemia, or other QT risk factors...
Frequently asked questions
Can I take Azithromycin and Domperidone together?
No — this combination should generally be avoided. Avoid co-prescribing where possible, especially in patients with cardiac disease, hypokalaemia, or other QT risk factors. Use alternative antiemetic or antibiotic therapy.
What is the severity of this interaction?
The interaction between Azithromycin and Domperidone is classified as Major — avoid combination. Both drugs can prolong cardiac repolarization through effects on cardiac potassium channels, increasing risk of QT prolongation and torsades de pointes.
What should I do if I'm prescribed both?
Avoid co-prescribing where possible, especially in patients with cardiac disease, hypokalaemia, or other QT risk factors. Use alternative antiemetic or antibiotic therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.