Azithromycin and Sotalol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Azithromycin and Sotalol unless specifically directed by your doctor.
How Azithromycin interacts with Sotalol
Both agents prolong the QT interval through blockade of the hERG potassium channel, with additive risk of torsades de pointes when combined.
What you should do
Avoid the combination; if unavoidable, obtain baseline and follow-up ECGs, correct hypokalaemia and hypomagnesaemia, and use the shortest azithromycin course possible.
Key facts
Severity
Major — avoid combination
Mechanism
Both agents prolong the QT interval through blockade of the hERG potassium channel, with additive risk of torsades de po...
Action
Avoid the combination; if unavoidable, obtain baseline and follow-up ECGs, correct hypokalaemia and hypomagnesaemia, and...
Frequently asked questions
Can I take Azithromycin and Sotalol together?
No — this combination should generally be avoided. Avoid the combination; if unavoidable, obtain baseline and follow-up ECGs, correct hypokalaemia and hypomagnesaemia, and use the shortest azithromycin course possible.
What is the severity of this interaction?
The interaction between Azithromycin and Sotalol is classified as Major — avoid combination. Both agents prolong the QT interval through blockade of the hERG potassium channel, with additive risk of torsades de pointes when combined.
What should I do if I'm prescribed both?
Avoid the combination; if unavoidable, obtain baseline and follow-up ECGs, correct hypokalaemia and hypomagnesaemia, and use the shortest azithromycin course possible. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.