Bictegravir and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Bictegravir and Rifampicin unless specifically directed by your doctor.
How Bictegravir interacts with Rifampicin
Rifampicin strongly induces CYP3A4 and UGT1A1, markedly lowering bictegravir concentrations and risking loss of virological suppression.
What you should do
Do not coadminister. Select an alternative antimicrobial or an antiretroviral regimen specifically compatible with rifampicin.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4 and UGT1A1, markedly lowering bictegravir concentrations and risking loss of virologi...
Action
Do not coadminister. Select an alternative antimicrobial or an antiretroviral regimen specifically compatible with rifam...
Frequently asked questions
Can I take Bictegravir and Rifampicin together?
No — this combination should generally be avoided. Do not coadminister. Select an alternative antimicrobial or an antiretroviral regimen specifically compatible with rifampicin.
What is the severity of this interaction?
The interaction between Bictegravir and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4 and UGT1A1, markedly lowering bictegravir concentrations and risking loss of virological suppression.
What should I do if I'm prescribed both?
Do not coadminister. Select an alternative antimicrobial or an antiretroviral regimen specifically compatible with rifampicin. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.