Bupropion and Metoprolol: Drug Interaction Guide

Quick answer: This combination requires caution. Bupropion and Metoprolol can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Bupropion interacts with Metoprolol

Bupropion is a potent CYP2D6 inhibitor and reduces metabolism of metoprolol, increasing plasma levels 4-5-fold and risk of bradycardia and hypotension.

What you should do

Initiate metoprolol at the lowest dose and titrate cautiously, or consider a beta-blocker not metabolised by CYP2D6 such as bisoprolol or atenolol.

Key facts

Severity

Moderate — caution required

Mechanism

Bupropion is a potent CYP2D6 inhibitor and reduces metabolism of metoprolol, increasing plasma levels 4-5-fold and risk ...

Action

Initiate metoprolol at the lowest dose and titrate cautiously, or consider a beta-blocker not metabolised by CYP2D6 such...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Bupropion and Metoprolol together?

With caution. Initiate metoprolol at the lowest dose and titrate cautiously, or consider a beta-blocker not metabolised by CYP2D6 such as bisoprolol or atenolol.

What is the severity of this interaction?

The interaction between Bupropion and Metoprolol is classified as Moderate — caution required. Bupropion is a potent CYP2D6 inhibitor and reduces metabolism of metoprolol, increasing plasma levels 4-5-fold and risk of bradycardia and hypotension.

What should I do if I'm prescribed both?

Initiate metoprolol at the lowest dose and titrate cautiously, or consider a beta-blocker not metabolised by CYP2D6 such as bisoprolol or atenolol. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.