Carvedilol and Digoxin: Drug Interaction Guide

Quick answer: This combination requires caution. Carvedilol and Digoxin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Carvedilol interacts with Digoxin

Carvedilol inhibits P-glycoprotein-mediated digoxin elimination and adds negative chronotropic effect at the AV node, raising digoxin levels by approximately 15-20%.

What you should do

Monitor heart rate, ECG, and digoxin concentration after initiation or dose change; consider a modest digoxin dose reduction in older or renally impaired patients.

Key facts

Severity

Moderate — caution required

Mechanism

Carvedilol inhibits P-glycoprotein-mediated digoxin elimination and adds negative chronotropic effect at the AV node, ra...

Action

Monitor heart rate, ECG, and digoxin concentration after initiation or dose change; consider a modest digoxin dose reduc...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Carvedilol and Digoxin together?

With caution. Monitor heart rate, ECG, and digoxin concentration after initiation or dose change; consider a modest digoxin dose reduction in older or renally impaired patients.

What is the severity of this interaction?

The interaction between Carvedilol and Digoxin is classified as Moderate — caution required. Carvedilol inhibits P-glycoprotein-mediated digoxin elimination and adds negative chronotropic effect at the AV node, raising digoxin levels by approximately 15-20%.

What should I do if I'm prescribed both?

Monitor heart rate, ECG, and digoxin concentration after initiation or dose change; consider a modest digoxin dose reduction in older or renally impaired patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.