Celecoxib and Fluconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Celecoxib and Fluconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Celecoxib interacts with Fluconazole

Fluconazole inhibits CYP2C9, the primary enzyme metabolising celecoxib, approximately doubling celecoxib plasma concentrations.

What you should do

Initiate celecoxib at half the usual recommended dose during fluconazole therapy and titrate based on response.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP2C9, the primary enzyme metabolising celecoxib, approximately doubling celecoxib plasma concentr...

Action

Initiate celecoxib at half the usual recommended dose during fluconazole therapy and titrate based on response.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Celecoxib and Fluconazole together?

With caution. Initiate celecoxib at half the usual recommended dose during fluconazole therapy and titrate based on response.

What is the severity of this interaction?

The interaction between Celecoxib and Fluconazole is classified as Moderate — caution required. Fluconazole inhibits CYP2C9, the primary enzyme metabolising celecoxib, approximately doubling celecoxib plasma concentrations.

What should I do if I'm prescribed both?

Initiate celecoxib at half the usual recommended dose during fluconazole therapy and titrate based on response. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.