Chloramphenicol and Gliclazide: Drug Interaction Guide

Quick answer: This combination requires caution. Chloramphenicol and Gliclazide can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Chloramphenicol interacts with Gliclazide

Chloramphenicol can inhibit hepatic metabolism of sulfonylureas such as gliclazide, increasing glucose-lowering effect. Additive illness-related reduced intake can further increase hypoglycemia risk.

What you should do

Monitor blood glucose closely and consider temporary sulfonylurea dose reduction. Advise patients on hypoglycemia symptoms and treatment.

Key facts

Severity

Moderate — caution required

Mechanism

Chloramphenicol can inhibit hepatic metabolism of sulfonylureas such as gliclazide, increasing glucose-lowering effect. ...

Action

Monitor blood glucose closely and consider temporary sulfonylurea dose reduction. Advise patients on hypoglycemia sympto...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Chloramphenicol and Gliclazide together?

With caution. Monitor blood glucose closely and consider temporary sulfonylurea dose reduction. Advise patients on hypoglycemia symptoms and treatment.

What is the severity of this interaction?

The interaction between Chloramphenicol and Gliclazide is classified as Moderate — caution required. Chloramphenicol can inhibit hepatic metabolism of sulfonylureas such as gliclazide, increasing glucose-lowering effect. Additive illness-related reduced intake can further increase hypoglycemia risk.

What should I do if I'm prescribed both?

Monitor blood glucose closely and consider temporary sulfonylurea dose reduction. Advise patients on hypoglycemia symptoms and treatment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.