Cholestyramine and Digoxin: Drug Interaction Guide

Quick answer: This combination requires caution. Cholestyramine and Digoxin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Cholestyramine interacts with Digoxin

Cholestyramine binds digoxin in the gut, reducing absorption and disrupting enterohepatic recirculation, leading to subtherapeutic digoxin concentrations.

What you should do

Administer digoxin at least 1 hour before or 4-6 hours after cholestyramine, and monitor digoxin levels and clinical response.

Key facts

Severity

Moderate — caution required

Mechanism

Cholestyramine binds digoxin in the gut, reducing absorption and disrupting enterohepatic recirculation, leading to subt...

Action

Administer digoxin at least 1 hour before or 4-6 hours after cholestyramine, and monitor digoxin levels and clinical res...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cholestyramine and Digoxin together?

With caution. Administer digoxin at least 1 hour before or 4-6 hours after cholestyramine, and monitor digoxin levels and clinical response.

What is the severity of this interaction?

The interaction between Cholestyramine and Digoxin is classified as Moderate — caution required. Cholestyramine binds digoxin in the gut, reducing absorption and disrupting enterohepatic recirculation, leading to subtherapeutic digoxin concentrations.

What should I do if I'm prescribed both?

Administer digoxin at least 1 hour before or 4-6 hours after cholestyramine, and monitor digoxin levels and clinical response. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.