Ciclosporin and Fluconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Ciclosporin and Fluconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ciclosporin interacts with Fluconazole

Fluconazole inhibits CYP3A4, reducing ciclosporin metabolism. Increased ciclosporin concentrations can cause nephrotoxicity, hypertension, and neurotoxicity.

What you should do

Monitor ciclosporin trough concentrations, renal function, and blood pressure. Dose reduction may be needed during fluconazole therapy and after discontinuation.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP3A4, reducing ciclosporin metabolism. Increased ciclosporin concentrations can cause nephrotoxic...

Action

Monitor ciclosporin trough concentrations, renal function, and blood pressure. Dose reduction may be needed during fluco...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ciclosporin and Fluconazole together?

With caution. Monitor ciclosporin trough concentrations, renal function, and blood pressure. Dose reduction may be needed during fluconazole therapy and after discontinuation.

What is the severity of this interaction?

The interaction between Ciclosporin and Fluconazole is classified as Moderate — caution required. Fluconazole inhibits CYP3A4, reducing ciclosporin metabolism. Increased ciclosporin concentrations can cause nephrotoxicity, hypertension, and neurotoxicity.

What should I do if I'm prescribed both?

Monitor ciclosporin trough concentrations, renal function, and blood pressure. Dose reduction may be needed during fluconazole therapy and after discontinuation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.