Duloxetine and Linezolid: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Duloxetine and Linezolid unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Duloxetine interacts with Linezolid

Linezolid is a reversible monoamine oxidase inhibitor; combined with the SNRI duloxetine it can precipitate serotonin syndrome.

What you should do

Avoid the combination. Stop duloxetine at least 5 days before starting linezolid and do not restart until 24 hours after linezolid is finished.

Key facts

Severity

Major — avoid combination

Mechanism

Linezolid is a reversible monoamine oxidase inhibitor; combined with the SNRI duloxetine it can precipitate serotonin sy...

Action

Avoid the combination. Stop duloxetine at least 5 days before starting linezolid and do not restart until 24 hours after...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Duloxetine and Linezolid together?

No — this combination should generally be avoided. Avoid the combination. Stop duloxetine at least 5 days before starting linezolid and do not restart until 24 hours after linezolid is finished.

What is the severity of this interaction?

The interaction between Duloxetine and Linezolid is classified as Major — avoid combination. Linezolid is a reversible monoamine oxidase inhibitor; combined with the SNRI duloxetine it can precipitate serotonin syndrome.

What should I do if I'm prescribed both?

Avoid the combination. Stop duloxetine at least 5 days before starting linezolid and do not restart until 24 hours after linezolid is finished. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.