Citalopram and Ondansetron: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Citalopram and Ondansetron unless specifically directed by your doctor.
How Citalopram interacts with Ondansetron
Both drugs prolong the QT interval through blockade of the hERG potassium channel; concurrent use additively increases risk of torsades de pointes.
What you should do
Avoid combination, particularly in patients with electrolyte disturbance, bradycardia, or other QT-prolonging drugs. Consider granisetron as alternative antiemetic.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs prolong the QT interval through blockade of the hERG potassium channel; concurrent use additively increases r...
Action
Avoid combination, particularly in patients with electrolyte disturbance, bradycardia, or other QT-prolonging drugs. Con...
Frequently asked questions
Can I take Citalopram and Ondansetron together?
No — this combination should generally be avoided. Avoid combination, particularly in patients with electrolyte disturbance, bradycardia, or other QT-prolonging drugs. Consider granisetron as alternative antiemetic.
What is the severity of this interaction?
The interaction between Citalopram and Ondansetron is classified as Major — avoid combination. Both drugs prolong the QT interval through blockade of the hERG potassium channel; concurrent use additively increases risk of torsades de pointes.
What should I do if I'm prescribed both?
Avoid combination, particularly in patients with electrolyte disturbance, bradycardia, or other QT-prolonging drugs. Consider granisetron as alternative antiemetic. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.