Citalopram and Sotalol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Citalopram and Sotalol unless specifically directed by your doctor.
How Citalopram interacts with Sotalol
Both drugs cause concentration-dependent QT interval prolongation through blockade of the hERG potassium channel, producing additive risk of torsades de pointes and sudden cardiac death.
What you should do
Avoid combination, particularly in patients with electrolyte disturbances, bradycardia, or congenital long QT. If essential, obtain baseline and follow-up ECGs, keep citalopram ≤20 mg, and correct potassium/magnesium.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs cause concentration-dependent QT interval prolongation through blockade of the hERG potassium channel, produc...
Action
Avoid combination, particularly in patients with electrolyte disturbances, bradycardia, or congenital long QT. If essent...
Frequently asked questions
Can I take Citalopram and Sotalol together?
No — this combination should generally be avoided. Avoid combination, particularly in patients with electrolyte disturbances, bradycardia, or congenital long QT. If essential, obtain baseline and follow-up ECGs, keep citalopram ≤20 mg, and correct potassium/magnesium.
What is the severity of this interaction?
The interaction between Citalopram and Sotalol is classified as Major — avoid combination. Both drugs cause concentration-dependent QT interval prolongation through blockade of the hERG potassium channel, producing additive risk of torsades de pointes and sudden cardiac death.
What should I do if I'm prescribed both?
Avoid combination, particularly in patients with electrolyte disturbances, bradycardia, or congenital long QT. If essential, obtain baseline and follow-up ECGs, keep citalopram ≤20 mg, and correct potassium/magnesium. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.