Citalopram and Tramadol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Citalopram and Tramadol unless specifically directed by your doctor.
How Citalopram interacts with Tramadol
Both drugs increase central serotonergic activity (citalopram via SERT inhibition, tramadol via SERT inhibition and serotonin release), with additive risk of serotonin syndrome.
What you should do
Avoid combination when possible. If necessary, use lowest tramadol dose, monitor for clonus, hyperreflexia, agitation, hyperthermia, and educate patient on warning signs.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs increase central serotonergic activity (citalopram via SERT inhibition, tramadol via SERT inhibition and sero...
Action
Avoid combination when possible. If necessary, use lowest tramadol dose, monitor for clonus, hyperreflexia, agitation, h...
Frequently asked questions
Can I take Citalopram and Tramadol together?
No — this combination should generally be avoided. Avoid combination when possible. If necessary, use lowest tramadol dose, monitor for clonus, hyperreflexia, agitation, hyperthermia, and educate patient on warning signs.
What is the severity of this interaction?
The interaction between Citalopram and Tramadol is classified as Major — avoid combination. Both drugs increase central serotonergic activity (citalopram via SERT inhibition, tramadol via SERT inhibition and serotonin release), with additive risk of serotonin syndrome.
What should I do if I'm prescribed both?
Avoid combination when possible. If necessary, use lowest tramadol dose, monitor for clonus, hyperreflexia, agitation, hyperthermia, and educate patient on warning signs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.