Clarithromycin and Digoxin: Drug Interaction Guide

Quick answer: This combination requires caution. Clarithromycin and Digoxin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Clarithromycin interacts with Digoxin

Clarithromycin inhibits intestinal P-glycoprotein and suppresses gut flora that inactivate digoxin, increasing digoxin bioavailability and serum levels.

What you should do

Monitor digoxin serum concentration and clinical signs of toxicity (nausea, arrhythmia, visual disturbance); consider reducing digoxin dose during macrolide therapy.

Key facts

Severity

Moderate — caution required

Mechanism

Clarithromycin inhibits intestinal P-glycoprotein and suppresses gut flora that inactivate digoxin, increasing digoxin b...

Action

Monitor digoxin serum concentration and clinical signs of toxicity (nausea, arrhythmia, visual disturbance); consider re...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Digoxin together?

With caution. Monitor digoxin serum concentration and clinical signs of toxicity (nausea, arrhythmia, visual disturbance); consider reducing digoxin dose during macrolide therapy.

What is the severity of this interaction?

The interaction between Clarithromycin and Digoxin is classified as Moderate — caution required. Clarithromycin inhibits intestinal P-glycoprotein and suppresses gut flora that inactivate digoxin, increasing digoxin bioavailability and serum levels.

What should I do if I'm prescribed both?

Monitor digoxin serum concentration and clinical signs of toxicity (nausea, arrhythmia, visual disturbance); consider reducing digoxin dose during macrolide therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.